The United States Agency for International Development (USAID) granted funding to FHI 360 for the implementation of Act to End Neglected Tropical Disease West (Act | West) program from July 19, 2018–July 18, 2023. The program is part of the global effort to eliminate neglected tropical diseases (NTDs). It particularly aims to eliminate lymphatic filariasis (LF), trachoma, and onchocerciasis (OV) (in certain countries) and control schistosomiasis (SCH) and soil-transmitted helminthiasis (STH) in 11 endemic West African countries—including Burkina Faso, Benin, Cameroon, Guinea, Ghana, Côte D’Ivoire, Mali, Niger, Senegal, Sierra Leone, and Togo. It also supports achievement of sustainable service delivery, with growing ownership of national governments in the elimination and/or control of NTDs. This report outlines the key achievements and challenges in the first six months of the second year of program implementation, spanning the period April 1, 2020–September 30, 2020.